Figure 1.

Pharmacokinetics after administration of 2 mg/kg of meclozine to mice is clinically relevant. (A) Plasma concentration-time course of meclozine was shown in 8-week-old wild-type mice after single administration of 2, 6, or 20 mg/kg of meclozine. The mean terminal elimination half-life (T_1/2) after a single dose of 25 mg of meclozine in human subjects was 5.21 hours (dotted line)¹⁷. Elevated plasma concentrations of meclozine were observed in a dose dependent manner (n = 3 for each group and each time point). (B) The average plasma concentrations of meclozine after 2 mg/kg administration were within the mean peak drug concentration (C_max) after a single dose of 25 mg of meclozine in human subjects (dotted line)¹⁷. Mean and SD are indicated. (C) There are no accumulation effects by repeated administration of 2 mg/kg of meclozine. Simulated curves of plasma concentration-time course of meclozine during repeated administration of 2, 6, or 20 mg/kg every 12 hours for seven days. Cumulative pharmacokinetics, which was observed in repeated administration of 20 mg/kg of meclozine, was not seen by repeated administration of 2 or 6 mg/kg of meclozine. ‘q 12 h’ means every 12 hours.