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. 2017 Aug 7;7:7371. doi: 10.1038/s41598-017-07044-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Administration of meclozine increases the trabecular bone area in the metaphysis of Fgfr3 ^ach mice. (A) Representative decalcified histology images of the distal femur stained with hematoxylin-eosin (HE) demonstrated that the trabecular bone was more abundant in 2 mg/kg/day of meclozine-treated Fgfr3 ^ach mouse than in untreated Fgfr3 ^ach mouse. Squared parts are magnified in lower panels. Scale bares indicate 400 μm in upper panels and 100 μm in lower panels. (B) Quantitative analyses of the trabecular area stained by HE showed that relative trabecular area was significantly increased by administration of 1 or 2 mg/kg/day of meclozine in Fgfr3 ^ach mice. Relative areas of the trabecular bones were calculated based on those of untreated Fgfr3 ^ach mice. Mean and SD are indicated. Statistical significance was analyzed by the unpaired t test for each dose of meclozine-treated Fgfr3 ^ach mice (n = 7 and 4 for 1 and 2 mg/kg/day of meclozine, respectively) or untreated wild-type mice (n = 11) versus untreated Fgfr3 ^ach mice (n = 10).