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. 2017 Aug 7;7:7468. doi: 10.1038/s41598-017-06983-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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MRI response to gas challenges. Mean changes in T ₁ relaxation times for different gas challenge regimes averaged across all animals (N = 4 per group) and standard error are shown for the liver, kidney cortex, and paraspinal muscle. Exception is 2% CO₂, which was studied in a single animal. Significant differences from baseline challenges are indicated (*P < 0.05).