Table 3.
Multivariate analysis of the impact of clinic-pathological features on the survival of oral squamous cell carcinoma patients based on subsites.
| Lip | Gum | Floor of mouth | Tongue | Buccal | Palate | RMT | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | HR | 95% CI | HR | 95% CI | HR | 95% CI | HR | 95% CI | HR | 95% CI | HR | 95% CI | |
| Age >50 years | 0.96 | 0.11–8.25 | 0.52 | 0.25–1.09 | 0 | 0–>10000 | 0.97 | 0.66–1.42 | 0.94 | 0.68–1.30 | 0.36 | 0.12–1.07 | 0.22 | 0–>10000 |
| Tumor grade | ||||||||||||||
| MD vs. WD | 0.90 | 0.09–9.55 | 0.81 | 0.24–2.80 | >1000 | 0–>10000 | 1.31 | 0.31–5.50 | 2.64 | 0.96–7.28 | 1.84 | 0.37–9.20 | 0.68 | 0–>10000 |
| PD vs. WD | 0.26 | 0.01–6.30 | 0.93 | 0.22–3.95 | >1000 | 0–>10000 | 2.17 | 0.50–9.46 | 3.70 | 1.31–10.49 | 3.03 | 0.57–16.21 | 0.57 | 0–>10000 |
| PNI | 0.25 | 0.04–1.47 | 1.14 | 0.47–2.77 | 10.50 | 0.57–194.4 | 1.54 | 1.03–2.31 | 1.14 | 0.77–1.68 | 4.33 | 0.91–20.56 | 0.18 | 0.09–96.36 |
| LVI | 6.78 | 0.71–64.29 | 3.01 | 1.31–6.91 | >1000 | 0–>10000 | 1.74 | 1.08–2.81 | 1.86 | 1.28–2.70 | 3.26 | 0.78–13.69 | >1000 | 0–>10000 |
| ECS | 0.91 | 0.09–8.94 | 1.12 | 0.40–3.13 | 0 | 0–>10000 | 1.51 | 0.95–2.39 | 1.43 | 0.95–2.16 | 0.11 | 0.02–0.59 | 1.74 | 0.19–15.79 |
| Margin <5 mm | 4.45 | 0.44–44.88 | 2.95 | 1.31–6.63 | 3.34 | 0.53–21.08 | 1.45 | 0.88–2.40 | 1.66 | 1.12–2.46 | 1.10 | 0.34–3.53 | 0 | 0–>10000 |
| Late stage | 5.53 | 0.74–41.46 | 1.88 | 0.73–4.84 | 71.38 | 0.67–7580 | 2.34 | 1.35–4.05 | 2.08 | 1.36–3.18 | 5.57 | 1.75–17.74 | 1.99 | 0–>10000 |
Abbreviations: RMT, retromolar trigone; HR, hazard ratio; CI, confidence interval; WD, well differentiated; MD, moderately differentiated; PD, poorly differentiated; PNI, perineural invasion; LVI, lymphovascular invasion; ECS, extra-capsular spread.