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. 2017 Aug 4;19(9):684–694. doi: 10.1016/j.neo.2017.05.007

Figure 6.

Figure 6

Histological assessment of vascular perfusion and permeability in intracranial MDA-MB-231 LM2–4 tumors in response to B20-4.1.1.

(A) Representative fluorescence images of the uptake of the perfusion marker Hoechst 33342 (blue), and the permeability marker Evans blue (red), acquired from brain sections taken from mice bearing intracranial MDA-MB-231 LM2–4 tumors treated with either isotype-matched control antibody Ragweed:1428 (control, n = 4) or B20-4.1.1 (n = 4). Tumor ROIs are shown in green. (B) Quantification of Hoechst 33342 perfused area and Evans blue positive area. Three sections per tumor were assessed and the mean for each tumor is represented.