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. 2017 Aug 7;17:151. doi: 10.1186/s12883-017-0927-x

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Flow chart of the patients and documented relapses. CIS = clinically isolated syndrome. IA = immunoadsorption. MP = methylprednisolone. PLEX = plasma exchange. RRMS = relapse-remitting multiple sclerosis. SMPS = secondary-progressive multiple sclerosis