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. 2017 Aug 7;7:38. doi: 10.1186/s13578-017-0166-2

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — The Hox genes are associated with ESC differentiation, but they are maintained inactive in ESCs due to the action of PcG proteins. Ash1l activates Hox genes through evicting Polycomb during differentiation. miR-290-295 cluster members downregulate the expression of Ash1l to maintain pluripotency