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. 2017 Aug 7;7:38. doi: 10.1186/s13578-017-0166-2

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — miR-290-295 cluster is causatively involved in MEF senescence. miR-290-295 cluster induces senescence through activation of INK4a/ARF locus, and the possible mechanism is to downregulate LRF with activation of p19ARF and p53, and p16INK4a up-regulation by EZH2 down-regulation