Table 2.

Definition of Early and Late RRT in Studies Included in the Meta-analysis

Author	Year	Early RRT Criteria	Late RRT Criteria
Bouman	2002	RRT within 12 h if urine output <30 ml/h, Cr clearance <20 ml/min, and mechanical ventilation	Urea > 40 mmol/L or K > 6.5 mmol/L or severe pulmonary edema
Durmaz	2003	Preoperative prophylactic RRT in all patients and postoperative sCr increased >10%	Postoperative sCr increased >50% or urine output <400 ml/24 h
Sugahara	2004	Urine output <30 ml/h for 3 h or urine output <750 ml/day	Urine output <20 ml/h for 2 h or urine output <500 ml/day
Payen	2009	RRT for 96-h period within 24 h of diagnosis of severe sepsis	Classic indications for RRT
Jamale	2013	Serum urea nitrogen >70 mg/dL and/or creatinine >7 mg/dL	Classic indications for RRT or Uremic nausea and anorexia
Combes	2015	RRT within 24 h of diagnosis of post-cardiac surgery shock	Creatinine >4 mg/dL or preoperative creatinine × 3 or urine output <0.3 ml/kg/h /24 h or urea >36 mmol/L or life-threatening hyperkalemia
Wald	2015	sCr increased >200%, urine output <6 ml/kg within 12 h, or NGAL ≥ 400 ng/ml	K > 6.0 mmol/L or serum bicarbonate <10 mmol/L or pulmonary edema
Gaudry	2016	RRT within 6 h of diagnosis of KDIGO stage 3	K > 6.0 mmol/L or PH < 7.15 or pulmonary edema or blood urea nitrogen >112 mg/dL or oliguria >72 h
Zarbock	2016	RRT within 8 h of diagnosis of KDIGO stage 2	RRT within 12 h of KDIGO stage 3 or no RRT

Abbreviations: RRT renal replacement therapy, Cr creatinine, sCr serum creatinine, K potassium, KDIGO kidney disease: improving global outcomes, NGAL neutrophil gelatinase-associated lipocalin