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. 2016 Dec 23;1:16030. doi: 10.1038/sigtrans.2016.30

Figure 5.

Figure 5

TIC PD-L1 sensitizes B16 and ID8agg to rapamycin. Fold change in numbers of B16 (a) TICs and non-TICs treated with 1.5 nm rapamycin for 48 h, versus medium alone. P-values, unpaired t-test. Absolute numbers of B16 TICs (b) and non-TICs (c). (d) Fold change in B16 Rptor expression by quantitative PCR (qPCR). Each bar represents fold increase in gene expression in TICs versus respective total cultures, with P-value for same directly over bar. P-values on horizontal lines compare fold changes between control (ctrl) and PD-L1lo cultures. Fold change in numbers of ID8agg (e) TICs and non-TICs treated similarly with 1.5 nm rapamycin for 48 h, versus medium alone. Absolute numbers of ID8agg TICs (f) and non-TICs (g). (h) ID8agg Rptor expression by qPCR. P-values, unpaired t-test.