Table 3.
Estimates for Braak Stage Adjusted Slopes of Cognitive Trajectory and Their 95% Confidence Intervals (Presented in Forward Time Scale).
| Outcome: | CDR-SOB | |||
|---|---|---|---|---|
| > 3-years before death | ≤ 3-years before death | |||
| Latent class | Braak stage | n | Estimate (95% CI) | Estimate (95% CI) |
| Overall (w/o Braak) | 920 | 1.17 (1.04, 1.30) | 2.02 (1.89, 2.16) | |
| 1 | High (5/6) | 402 | 2.13 (1.97, 2.28) | 2.99 (2.84, 3.15) |
| Moderate (3/4) | 58 | 1.55 (1.17, 1.92) | 2.51 (2.18, 2.84) | |
| Low (0/1/2) | 11 | 1.60 (1.00, 2.21) | 2.72 (2.21, 3.22) | |
| 2 | High (5/6) | 318 | 0.37 (0.20, 0.53) | 1.23 (1.07, 1.40) |
| Moderate (3/4) | 95 | –0.22 (–0.58, 0.15) | 0.75 (0.42, 1.08) | |
| Low (0/1/2) | 36 | –0.16 (–0.75, 0.44) | 0.96 (0.46, 1.46) | |
| Contrast a | High vs Mod | 0.58 (0.19, 0.97) | 0.49 (0.15, 0.83) | |
| High vs Low | 0.52 (–0.09, 1.14) | 0.28 (–0.24, 0.79) | ||
| Mod vs Low | –0.06 (–0.75, 0.64) | –0.21 (–0.79, 0.37) | ||
| Outcome: | Logical memory | |||
| > 2-years before death | ≤ 2-years before death | |||
| Latent class | Braak Stage | n | Estimate (95% CI) | Estimate (95% CI) |
| Overall (w/o Braak) | 649 | –0.68 (–0.78, –0.57) | –0.74 (–1.02, –0.46) | |
| 1 | High (5/6) | 447 | –0.45 (–0.57, –0.32) | –0.78 (–1.07, –0.48) |
| Moderate (3/4) | 130 | –0.45 (–0.65, –0.26) | –0.78 (–1.10, –0.47) | |
| Low (0/1/2) | 39 | –0.06 (–0.38, 0.25) | –0.40 (–0.78, –0.01) | |
| 2 | High (5/6) | 28 | –2.00 (–2.26, –1.75) | –2.34 (–2.72, –1.95) |
| Moderate (3/4) | 4 | –2.01 (–2.32, –1.70) | –2.34 (–2.76, –1.93) | |
| Low (0/1/2) | 1 | –1.62 (–2.02, –1.23) | –1.96 (–2.42, –1.49) | |
| Contrast a | High vs Mod | 0.01 (–0.19, 0.21) | 0.01 (–0.19, 0.21) | |
| High vs Low | –0.38 (–0.70, –0.06) | –0.38 (–0.70, –0.06) | ||
| Mod vs Low | –0.39 (–0.73, –0.04) | –0.39 (–0.73, –0.04) | ||
| Outcome: | Vegetable naming | |||
| > 3-years before death | ≤ 3-years before death | |||
| Latent class | Braak Stage | n | Estimate (95% CI) | Estimate (95% CI) |
| Overall (w/o Braak) | 520 | –0.89 (–1.00, –0.77) | –0.89 (–1.02, –0.75) | |
| 1 | High (5/6) | 65 | –0.70 (–0.98, –0.43) | –0.73 (–1.01, –0.44) |
| Moderate (3/4) | 21 | –0.49 (–0.91, –0.08) | –0.60 (–1.03, –0.17) | |
| Low (0/1/2) | 8 | 0.07 (–1.07, 1.20) | –0.95 (–1.72, –0.18) | |
| 2 | High (5/6) | 325 | –0.97 (–1.15, –0.80) | –0.99 (–1.25, –0.74) |
| Moderate (3/4) | 79 | –0.76 (–1.16, –0.36) | –0.87 (–1.27, –0.46) | |
| Low (0/1/2) | 22 | –0.20 (–1.32, 0.92) | –1.22 (–1.97, –0.46) | |
| Contrast a | High vs Mod | –0.21 (–0.64, 0.21) | –0.13 (–0.59, 0.33) | |
| High vs Low | –0.77 (–1.90, 0.36) | 0.22 (–0.56, 1.01) | ||
| Mod vs Low | –0.56 (–1.74, 0.62) | 0.35 (–0.50, 1.20) |
a
Contrasts among Braak stages are the same for both latent classes.