Fig. 2.

Illustration of AMMs on a protein-folding model with true thermodynamics and kinetics shown in green. A representative biased simulation with $\mathrm{\Delta }\mathrm{\Delta }{G}_{\text{fold}}\approx -\mathrm{\hspace{0.17em}3}kT$ compared with the true model is shown in blue whereas the AMM-corrected values are shown in magenta. (A) Kinetic network topology. Each state is annotated by its true free energy in $kT$. (B and C) Equilibrium distributions (solid line) and expectation values (dashed/dashed-dotted lines) of helicity and fluorescence quenching observables. (D and E) Mean first passage times of folding and unfolding, respectively, of biased and AMM models as a function of the degree of bias, $\mathrm{\Delta }\mathrm{\Delta }{G}_{\text{fold}}$ (Materials and Methods).