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. 2017 Jul 17;114(31):8384–8389. doi: 10.1073/pnas.1704984114

Fig. 5.

Fig. 5.

Analysis of the sensitivity and specificity of the BOB NS1 ELISA. (A) The values of BOB inhibition in samples from subjects diagnosed with ZIKV or DENV infection by RT-PCR are shown. The DENV group consists of samples from primary and secondary DENV cases from Nicaragua and Italy. The control group identified as “all” comprises DENV samples as well as samples from patients infected (or vaccinated) with other flaviviruses (i.e., WNV and YFV) or with CHIKV, samples from patients with other illnesses and samples from healthy blood donors. (B) Sensitivity calculated on the basis of different time-point cutoff values, and specificity calculated using different control groups. The flaviviruses group comprises samples from DENV and WNV cases and YFV vaccinees. The control group identified as “+ other illnesses” comprises the samples from the flavivirus group, as well as samples with CHIKV and other illnesses (Brazilian samples collected before 2014).