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Recruitment of BRIT1 and 53BP1 to S region DNA is independent of each other. (A) ChIP-qPCR analysis of H3, BRIT1, and 53BP1 occupancy at the Sμ region in activated splenic B cells from Mb1-Cre control, BRIT1 KO, 53BP1 KO, and AID KO mice (n = 3; **P < 0.005, *P < 0.05). ns, not significant. (B) Immunoblot analysis of whole-cell extracts from cells that were cross-linked for ChIP analysis.
