Table 2. Multivariate models of annualized relapse rate over the observation period and EDSS 10 years after symptom onset.

	Annualized relapse rate ≥ 0.4			EDSS ≥ 4 ten years after symptom onset
	OR1	95% confidence interval	P value	OR1	95% confidence interval	P value
PS/US onset	0.78	0.45–1.05	0.123	0.91	0.23–1.71	0.769
Female	1.38	0.91–2.11	0.133	0.93	0.87–0.99	0.049
Complete remission after 6 months	1.10	0.68–1,79	0.691	0.85	0.73–0.96	0.023
Age at initial symptoms (per 5 years)	0.96	0.94–0.98	0.038	1.09	1.05–1.13	0.041
Number of T2 lesions (per lesion)	1.01	1.00–1.02	0.031	1.12	1.09–1.15	0.032
Number of CE lesions (per lesion) *	1.32	1.21–1.43	0.003	1.31	1.14–1.57	0.018
Positive OCB **	0.77	0.36–1.67	0.513	1.29	0.86–1.77	0.436
DMT exposure	0.49	0.34–0.73	<0.001	0.90	0.81–0.98	0.025

¹Calculated by binary logistic regression models: OR values between > 1 indicating higher risk of an annualized relapse rate ≥ 0.4 over the observation period and an EDSS ≥ 4 10 years after symptom onset, respectively.

* available from 473 patients;

** available from 503 patients.

EDSS: expanded disability status scale; PS: paroxysmal symptom; US: unusual symptom; CE: contrast-enhancing; OCB: oligoclonal bands; DMT: disease modifying treatment; OR: odds ratio.