Table 1.

The current methods used to identify risk in CML.

Previous methods
Study	Factors	Method	Target prediction	Data and results
Sokal score, Sokal et al. [78]	Age, spleen size (cm), blast (%), and platelets (109/L)	Multivariate analysis of survival	Risk groups for chemotherapy	Six European and American sources (n = 813), low 39%, intermediate 38%, and high 23%
Hasford score, Hasford et al. [79]	Age, spleen size (cm), blasts (%), eosinophils (%), basophils (%), and platelets (109/L)	Multivariate analysis of survival	Risk groups for interferon alpha alone	14 studies (n = 981), low 40.6%, intermediate 44.7%, and high 14.6%
EUropean Treatment Outcome Study (EUTOS) Score, Hasford et al. [80]	Basophils (%) and spleen size (cm)	Multivariate analysis of response	CCgR at 18 months to Imatinib	Five national study groups (n = 2,060), low 79% and high 21%
EUTOS Long-Term survival (ELTS) score, Hoffmann et al. [81]	Age, spleen size (cm), blast (%), and platelets (109/L)	Multivariate analysis of response	Long-term survival	(n = 2,205) low 61%, intermediate 27%, and high 12%