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. 2017 Jul 25;2017:6157491. doi: 10.1155/2017/6157491

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Copyright © 2017 Andreas Bayer et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

HBD-3 is induced by Vivostat PRF treatment in vivo. In the in vivo study, we observed a strong hBD-3 gene induction by artificial wound generation which was significantly increased by local wound therapy by Vivostat PRF (a) (^∗p < 0.05, ^∗∗∗p < 0.001, Student's t-test). (b) Correspondingly, using immunohistochemistry, we observed a strong hBD-3 induction in the uppermost epidermal layers of artificially generated skin wounds (control day 10) that was intensified by a local Vivostat PRF wound treatment on day 0 and day 5 of the conducted study. Scale bars represent 50 μm.