Table 3. Epidemiologic and economic burden (median (95% credibility range), costs in millions ($US)) of CRE infections in the United States assuming a 26% attributable mortality and meropenem use for carbapenem therapies.
CRE incidence per 100 000 | ||||
---|---|---|---|---|
|
||||
2.93 | 6 | 10 | 15 | |
Infections | 9418 | 19 285 | 32 142 | 48 213 |
Deaths | 840 | 1721 | 2868 | 4301 |
QALYs lost | 8841 (5805–12 420) | 18 105 (11 888–25 433) | 30 174 (19 814–42 388) | 45 261 (29 720–63 581) |
Hospital perspective | 275 (217–334) | 562 (443–685) | 937 (739–1141) | 1406 (1109–1712) |
Third-party payer perspective | 147 (129–172) | 302 (264–353) | 503 (440–588) | 754 (661–882) |
Productivity losses because of absenteeism | 11 (5–46) | 22 (9–94) | 37 (16–157) | 56 (24–236) |
Productivity losses because of death | 389 (149–1407) | 796 (306–2882) | 1327 (509–4803) | 1990 (764–7205) |
Societal perspective | 553 (303–1593) | 1132 (620–3262) | 1886 (1034–5437) | 2830 (1550–8155) |