Skip to main content
. 2017 Jul 24;7(3):498–506. doi: 10.3892/mco.2017.1342

Table II.

Summary of the meta-analysis results.

A, Overall survival
Random-effects model Fixed-effects model Heterogeneity
Subgroup Number HR (95% CI) P-value HR (95% CI) P-value I2 (%) Ph
Treatment
  Surgery   7 1.57 (1.21–1.95) <0.001 1.25 (1.19–1.31) <0.001 88.3 <0.001
  Non-surgery 10 1.42 (1.21–1.68) <0.001 1.11 (1.06–1.16) <0.001 75.9 <0.001
Ethnicity
  Caucasian   5 1.58 (1.15–2.17)   0.005 1.14 (1.08–1.22) <0.001 80.9 <0.001
  Asian 10 1.51 (1.26–1.81) <0.001 1.17 (1.12–1.21) <0.001 87.7 <0.001
Tumor stage
  Late   5 1.43 (1.09–1.87) 0.1 1.08 (1.03–1.13)   0.001 80.2 <0.001
  Early   8 1.64 (1.37–1.97) <0.001 1.50 (1.39–1.62) <0.001 65.9   0.005
Sample size, n
  <200   7 1.25 (1.11–1.41) <0.001 1.09 (1.05–1.13) <0.001 74.1   0.001
  ≥200 10 1.56 (1.35–1.79) <0.001 1.48 (1.38–1.59) <0.001 60.3   0.007
Cut-off value
  <4 10 1.44 (1.24–1.66) <0.001 1.14 (1.10–1.18) <0.001 88.2 <0.001
  ≥4   5 1.56 (1.31–1.85) <0.001 1.55 (1.32–1.81) <0.001 14.3   0.323
Type
  NSCLC 15 1.45 (1.28–1.64) <0.001 1.16 (1.12–1.20) <0.001 85.2 <0.001
  SCLC   2 1.53 (1.23–1.89) <0.001 1.53 (1.23–1.89) <0.001 0   0.792
Method
  Multivariate 16 1.50 (1.32–1.70) <0.001 1.17 (1.13–1.21) <0.001 85.2 <0.001
  Univariate 12 1.51 (1.28–1.78) <0.001 1.17 (1.13–1.22) <0.001 87.4 <0.001
B, Progression-free survival
Ethnicity
  Caucasian 3 1.43 (1.14–1.80)   0.002 1.43 (1.14–1.80)   0.002 0   0.735
  Asian 5 1.40 (1.07–1.83)   0.015 1.06 (1.01–1.12)   0.024 82.1 <0.001
Sample size, n
  <200 6 1.44 (1.09–1.90) 0.1 1.06 (1.00–1.11)   0.034 77.1   0.001
  ≥200 2 1.41 (1.15–1.72)   0.001 1.41 (1.15–1.72)   0.001 0   0.683
Cut-off value
  <4 3 1.27 (0.93–1.72)   0.128 1.04 (0.99–1.09)   0.158 88.2 <0.001
  ≥4 5 1.54 (1.13–1.82) <0.001 1.54 (1.30–1.82) <0.001 57.2   0.029
Type
  NSCLC 6 1.38 (1.08–1.75) 0.1 1.06 (1.00–1.11)   0.4 72.9   0.002
  SCLC 2 1.54 (1.24–1.92) <0.001 1.54 (1.24–1.92) <0.001 0   0.761
Method
  Multivariate 6 1.38 (1.10–1.74)   0.027 1.07 (1.02–1.13)   0.008 80.5 <0.001
  Univariate 5 1.35 (1.03–1.75)   0.002 1.05 (1.00–1.11)   0.046 77   0.002

OS, overall survival; PFS, progression-free survival; NSCLC, non-small-cell lung cancer; SCLC, small-cell lung cancer; HR, hazard ratio; CI, confidence interval; Ph, P-value of Q-test for heterogeneity.