Table. Features for children from Ethiopia with Bartonella quintana endocarditis*.
Patient, age, y/sex |
Echo finding |
Underlying condition |
Phenomena |
Microbiologic evidence |
CRP, mg/dL |
ESR, mm/h |
Leuk/mm3 |
Hb, g/dL |
Platelets/ mm3† |
|
Vascular |
Immunologic |
|||||||||
A, 7/F |
Several vegetations (11 mm) on pulmonary valve |
CHD |
No |
RF Ab, 189 IU/mL |
Bartonella IgG titer 1:1,600, IgM neg; excised vegetation PCR-neg for Coxiella burnetii, PCR-pos for B. quintana‡ |
1.7 |
128 |
3,500 |
8.5 |
150,000 |
B, 12/F |
Vegetation (7 mm) on mitral valve |
RHD |
No |
RF Ab, <10 IU/mL |
Bartonella IgG titer 1:100, IgM neg; excised vegetation PCR-neg for C. burnetii, PCR-pos for B. quintana‡ |
0.7 |
50 |
5,700 |
10.3 |
310,000 |
C, 16/F |
Two vegetations (5 mm) on aortic valve |
RHD |
Emboli to spleen |
GN; 16 Osler nodes |
Bartonella IgG titer 1:12,800 (10 wks after surgery: 1:6,400); excised vegetation PCR-neg for C. burnetii, PCR-pos for B. quintana‡ |
4.2 |
150 |
6,900 |
7.8 |
334,000 |
D, 9/F |
Several vegetations (10 mm and 20 mm) on aortic valve |
CHD |
CVA |
RF Ab, 25 IU/mL |
Bartonella IgG titer 1:6,400 (5 wks after surgery: 1:1,600); excised vegetation PCR-neg for C. burnetii, PCR-pos for B. quintana‡ |
1.5 |
44 |
6,100 |
11.7 |
189,000 |
E, 11/M | Vegetation (14 mm) on aortic valve | CHD | No | RF Ab, 2,560 IU/mL | Bartonella IgG titer 1:6,400; C. burnetii IgM neg | 2.0 | 110 | 9,100 | 11.8 | 264,000 |
*HIV serologic testing and blood culture results were negative for all patients, and no patients had fever. Ab, antibody; CHD, congenital heart disease CRP, C-reactive protein (reference range 0–10 mg/dL); CVA, cerebral vascular accident; Echo, echocardiogram; ESR, erythrocyte sedimentation rate (reference range 0–20 mm); GN, glomerulonephritis; Hb, hemoglobin (reference range 9.5–13.0 g/dL); Leuk, leukocytes (reference range 6,000–17,500 cells/mm3); neg, negative; pos, positive; RF, rheumatoid factor; RHD, rheumatic heart disease. †Reference range 150–400 × 109 platelets/L. ‡Sequence comparison analysis demonstrated a 100% identity to B. quintana.