Table 1. Main clinical and biologic characteristics of the 12 patients who had received solid organ transplants and 20 control patients in a study of a Pneumocystis jirovecii pneumonia outbreak at a university hospital in France, 2009–2015*.
Patient | Age, y/sex | Date of diagnosis | Underlying condition | Time since transplant, mo | Sample type | Fungal load, MSG copies/mL | Outcome |
---|---|---|---|---|---|---|---|
T1 | 34/F | 2014 May 20 | Pulmonary transplant | 60 | BAL | 1.1 × 109 | Died |
T2 | 59/F | 2014 May 27 | Heart and kidney transplant | 300 (H) – 2 (K) | BAL | 3.9 × 108 | Survived |
T3 | 57/F | 2014 Jun 19 | Heart transplant | 137 | BAL | 2.7 × 108 | Died |
T4 | 65/M | 2014 Jul 7 | Heart transplant | 37 | BAL | 1.5 × 108 | Died |
T5 | 66/M | 2014 Aug 19 | Kidney transplant | 4 | Sputum | 6.6 × 1010 | Survived |
T6 | 48/M | 2014 Aug 29 | Heart transplant | 78 | BAL | 1 × 106 | Survived |
T7 | 74/F | 2014 Oct 29 | Kidney transplant | 128 | BAL | 2 × 107 | Died |
T8 | 69/F | 2014 Nov 24 | Kidney transplant | 23 | BAL | 8.8 × 106 | Survived |
T9 | 63/M | 2015 Jan 7 | Liver transplant | 5 | BAL | 1.1 × 104 | Survived |
T10 | 69/M | 2015 Jan 10 | Kidney transplant | 228 | Sputum | 1.2 × 105 | Survived |
T11 | 61/F | 2015 Mar 3 | Heart transplant | 122 | BAL | 3.1 × 103 | Survived |
T12 | 75/F | 2015 Aug 26 | Heart transplant | 95 | BAL | 2 × 105 | Survived |
C1 | 56/M | 2012 Aug 25 | Liver transplant | 6 | BA | 6 × 106 | Died (HCV relapse) |
C2 | 52/M | 2013 May 17 | Pulmonary transplant | 21 | BAL | 1.7 × 105 | Survived |
C3 | 82/F | 2012 Mar 9 | Rheumatoid polyarthritis | – | BAL | 5.6 × 103 | Survived |
C4 | 62/M | 2013 Aug 29 | NHL | – | BAL | 4.3 × 108 | Survived |
C5 | 66/M | 2013 Sep 10 | NHL | – | BAL | 1.2 × 106 | Survived |
C6 | 25/M | 2014 Feb 27 | HIV | – | BAL | 4.2 × 108 | Survived |
C7 | 1/F | 2014 Apr 9 | Primary immunodeficiency | – | BAL | 5.2 × 109 | Survived |
C8 | 56/M | 2014 Apr 19 | HIV | – | BAL | 4.3 × 109 | Survived |
C9 | 47/F | 2014 Apr 24 | Allografted AML with GVHD | – | BAL | 1.4 × 106 | Survived |
C10 | 74/M | 2014 Jul 1 | NHL | – | BAL | 6.1 × 108 | Survived |
C11 | 77/M | 2014 Sep 4 | MPN and NHL | – | BAL | 1.2 × 105 | Survived |
C12 | 82/M | 2014 Sep 5 | NHL | – | BAL | 5.8 × 104 | Survived |
C13 | 68/M | 2014 Oct 10 | Glioblastoma | – | BAL | 3.4 × 1010 | Survived |
C14 | 7 mo/F | 2014 Oct 15 | Primary immunodeficiency | – | Sputum | 4.7 × 106 | Survived |
C15 | 75/F | 2014 Oct 23 | B-chronic lymphoid leukemia | – | BAL | 3.4 × 105 | Survived |
C16 | 82/F | 2014 Dec 5 | B-chronic lymphoid leukemia | – | BAL | 1.1 × 104 | Survived |
C17 | 32/F | 2015 Feb 27 | Hodgkin's disease | – | BAL | 1.2 × 104 | Survived |
C18 | 50/M | 2015 Feb 28 | Hodgkin's disease | – | BAL | 6.4 × 103 | Survived |
C19 | 78/M | 2015 Mar 18 | B-chronic lymphoid leukemia | – | BAL | 5.9 × 106 | Survived |
C20 |
75/M |
2015 Mar 22 |
NHL |
– |
BA |
3.9 × 104 |
Died |
*T1–T12 indicate the 12 solid organ transplant patients from the cluster; C1–C20 indicate the 20 control patients. AML, acute myeloid leukemia; BA, bronchoaspiration; BAL, bronchoalveolar lavage fluids; GVHD, graft-versus-host disease; H, heart; K, kidney; MPN, myeloproliferative neoplasm; MSG, major surface glycoprotein; NA, not applicable; ND, not done; NHL, non-Hodgkin lymphoma; –, nonexistent or unspecified. |