Table 2. Responders and Nonresponders With CMCs in QOL at Day 10a.
| Domain/Item | No. (%) of Patients | P Value | |||
|---|---|---|---|---|---|
| Responders | Nonresponders | ||||
| QOL CMCs |
QOL Non-CMCs |
QOL CMCs |
QOL Non-CMCs |
||
| QOL change ≥10 | |||||
| Physical functioning | 26 (26.0) | 74 (74.0) | 32 (27.8) | 83 (72.2) | .76 |
| Emotional functioning | 31 (31.0) | 69 (69.0) | 27 (23.7) | 87 (76.3) | .23 |
| Global QOL | 34 (34.3) | 65 (65.7) | 36 (32.0) | 77 (68.0) | .70 |
| Functional interference | 43 (43.0) | 57 (57.0) | 37 (32.2) | 78 (67.8) | .10 |
| Psychosocial aspects | 37 (37.0) | 63 (63.0) | 24 (20.9) | 91 (79.1) | .009b |
| QOL change ≤10 | |||||
| Pain | 51 (54.3) | 43 (45.7) | 49 (43.0) | 65 (57.0) | .11 |
| Fatigue | 29 (29.0) | 71 (71.0) | 31 (27.4) | 82 (72.6) | .80 |
| Nausea | 17 (17.0) | 83 (83.0) | 21 (18.3) | 94 (81.7) | .81 |
| Dyspnea | 13 (13.3) | 85 (86.7) | 19 (16.8) | 94 (83.2) | .47 |
| Insomnia | 27 (27.3) | 72 (72.7) | 29 (25.4) | 85 (74.6) | .76 |
| Appetite | 19 (19.0) | 81 (81.0) | 27 (23.5) | 88 (76.5) | .42 |
| Constipation | 22 (22.2) | 77 (77.8) | 19 (16.7) | 95 (83.3) | .31 |
| Painful sites | 36 (36.0) | 64 (64.0) | 32 (27.8) | 83 (72.2) | .20 |
| Pain characteristics | 64 (64.0) | 36 (36.0) | 49 (42.6) | 66 (57.4) | .002b |
Abbreviations: CMCs, clinically meaningful changes; QOL, quality of life.
a
Sample sizes vary.
b
Statistically significant (P < .05).