Table 3. Responders and Nonresponders With CMCs in QOL at Day 42a.
| Domain/Item | No. (%) of Patients | P Value | |||
|---|---|---|---|---|---|
| Responders | Nonresponders | ||||
| QOL CMCs |
QOL Non-CMCs |
QOL CMCs |
QOL Non-CMCs |
||
| QOL change ≥10 | |||||
| Physical functioning | 41 (40.6) | 60 (59.4) | 19 (22.4) | 66 (77.6) | .008b |
| Emotional functioning | 51 (50.0) | 51 (50.0) | 26 (30.6) | 59 (69.4) | .007b |
| Global QOL | 56 (56.0) | 44 (44.0) | 22 (25.9) | 63 (74.1) | <.001b |
| Functional interference | 66 (64.7) | 36 (35.3) | 38 (44.7) | 47 (55.3) | .006b |
| Psychosocial aspects | 43 (42.2) | 59 (57.8) | 23 (27.1) | 62 (72.9) | .03b |
| QOL change ≤10 | |||||
| Pain | 71 (71.7) | 28 (28.3) | 43 (50.6) | 42 (49.4) | .003b |
| Fatigue | 43 (42.2) | 59 (57.8) | 17 (20.2) | 67 (79.8) | .002b |
| Nausea | 20 (19.6) | 82 (80.4) | 17 (20.0) | 68 (80.0) | .95 |
| Dyspnea | 22 (21.6) | 80 (78.4) | 11 (13.1) | 73 (86.9) | .13 |
| Insomnia | 36 (35.3) | 66 (64.7) | 20 (23.8) | 64 (76.2) | .09 |
| Appetite | 23 (22.5) | 79 (77.5) | 17 (20.0) | 68 (80.0) | .67 |
| Constipation | 34 (33.3) | 68 (66.7) | 16 (19.3) | 67 (80.7) | .03b |
| Painful sites | 59 (57.8) | 43 (42.2) | 31 (36.5) | 54 (63.5) | .004b |
| Pain characteristics | 74 (72.5) | 28 (27.5) | 44 (51.8) | 41 (48.2) | .003b |
Abbreviations: CMCs, clinically meaningful changes; QOL, quality of life.
a
Sample sizes vary.
b
Statistically significant (P < .05).