Table 2. Real-time qRT-PCR analysis of TRKA mRNA levels in primary AML patient samples.
| Cluster | Nos. in cluster | Nos. >2-fold | Proportion >2-fold | P value for 2-fold | Nos. >5-fold | Proportion >5-fold | P value for 5-fold |
|---|---|---|---|---|---|---|---|
| 1 | 12 | 1 | 0.083 | 1 | 1 | 0.083 | 1 |
| 2 | 17 | 3 | 0.176 | 1 | 0 | 0.000 | 1 |
| 3 | 18 | 9 | 0.500 | 0.0032 | 2 | 0.111 | 0.9989 |
| 4 | 15 | 2 | 0.133 | 1 | 0 | 0.000 | 1 |
| 5 | 42 | 0 | 0.000 | 1 | 0 | 0.000 | 1 |
| 6 | 8 | 1 | 0.125 | 1 | 0 | 0.000 | 1 |
| 7 | 18 | 1 | 0.056 | 1 | 0 | 0.000 | 1 |
| 8 | 12 | 0 | 0.000 | 1 | 0 | 0.000 | 1 |
| 9 | 21 | 10 | 0.476 | 0.0027 | 4 | 0.190 | 0.2675 |
| 10 | 23 | 5 | 0.217 | 0.9999 | 1 | 0.043 | 1 |
| 11 | 9 | 0 | 0.000 | 1 | 0 | 0.000 | 1 |
| 12 | 19 | 6 | 0.316 | 0.7945 | 3 | 0.158 | 0.5398 |
| 13 | 21 | 10 | 0.476 | 0.0027 | 7 | 0.333 | 0.0005 |
| 14 | 10 | 0 | 0.000 | 1 | 0 | 0.000 | 1 |
| 15 | 8 | 1 | 0.125 | 1 | 1 | 0.125 | 1 |
| 16 | 11 | 0 | 0.000 | 1 | 0 | 0.000 | 1 |
Numbers in cluster are the number of patient samples in each cluster. Numbers >2-fold (or 5-fold) are number of sample with TRKA mRNA levels ≥2-fold (or 5-fold) the level of expression in CD34 selected bone marrow cells. Proportion >2-fold (or 5-fold) is the percentage of samples in that cluster with >2-fold (or 5-fold) TRKA mRNA levels, relative to CD34+ bone marrow cells. P values are provided for the proportion of samples with a >2-fold (or >5-fold) increase in TRKA mRNA levels.