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. 2017 Jul 3;40(3):762–770. doi: 10.3892/ijmm.2017.3047

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Copyright: © Yang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Radioprotective effects of simvastatin on mouse thymi after radiation are related to p53 expression/phosphorylation (B) and AKT/sirtuin 1 (A), poly(ADP-ribose) polymerase (PARP) expression (C) in vivo. (D–G) The quantitative results of AKT, sirtuin 1, p53 and PARP expression 3 days after radiation are shown. At 3 days after irradiation, the expression of (D) AKT, (E) sirtuin 1 and (G) PARP was significantly decreased in the radiated mouse thymus, while simvastatin significantly augmented their expression. (F) Compared to the radiated group, p53 expression was significantly suppressed by simvastatin (F). Values are the means ± SEM. C, control; S, simvastatin; R, ionizing radiation; radiation + simvastatin (RS), IR + simvastatin; n=6, ^**P<0.01 vs. C group; ^##P<0.01 vs. R group (One-way ANOVA, Newman-Keuls multiple comparison test).