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. 2017 Jul 6;16(3):2611–2619. doi: 10.3892/mmr.2017.6936

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Copyright: © Zhao et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — Effects of PZH-GB on histopathological changes induced by CCl₄ in rats. The rats were pretreated with PZH-GB (150, 300 and 600 mg/kg), silymarin (50 mg/kg) or vehicle for 7 days before administration of CCl₄ (2 ml/kg body weight and 1:1 diluted in corn oil) to induce acute liver injury. Representative pictures of liver sections stained with hematoxylin and eosin (magnification, ×200) are presented. (−), no inflammation or ballooning degeneration; (+), inflammation or ballooning degeneration occupying 33% of the hepatic parenchyma; (+++), inflammation or ballooning degeneration occupying >66% of the hepatic parenchyma. PZH-GB, Pien Tze Huang Gan Bao; CCl₄, carbon tetrachloride; GB, PZH-GB.