Table I.
Quantification analysis for histopathologic changes.
| Liver injury | |||||
|---|---|---|---|---|---|
| Group | Rats (n) | − | + | ++ | +++ |
| Control | 10 | 10 | 0 | 0 | 0 |
| Model | 10 | 0 | 0 | 2 | 8a |
| Silymarin | 10 | 1 | 3 | 4 | 2b |
| GB-150 mg/kg | 10 | 0 | 4 | 3 | 3b |
| GB-300 mg/kg | 10 | 0 | 4 | 4 | 2b |
| GB-600 mg/kg | 10 | 2 | 4 | 2 | 2b |
To evaluate the degree of necrosis after acute liver injury, an injury grading score based on severity of necrotic lesions in the liver parenchyma was created. Data were analyzed by Chi-squared test.
a
P<0.05 vs. control group
b
P<0.05 vs. CCl4-treated group. (−), grade 0, no inflammation or ballooning degeneration; (+), grade 1, inflammation or ballooning degeneration occupying 33% of the hepatic parenchyma; (++), grade 2, inflammation or ballooning degeneration occupying 33-66% of the hepatic parenchyma; (+++), grade 3, inflammation or ballooning degeneration occupying >66% of the hepatic parenchyma.