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TLR4 expression was increased in lung tissues from COPD rats. There is basal expression of TLR4 in control rat pulmonary artery smooth muscle layer (A, magnification, ×400). However, TLR4 expression was increased in pulmonary artery smooth muscle layer of COPD rats (B, magnification, ×400). The pulmonary arteries are marked with arrow, and brown staining is the positive TLR4 protein. TLR4, Toll-like receptor 4; COPD, chronic obstructive pulmonary disease.
