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TLR4 inhibitor TAK-242 suppresses the TLR4/IRAK/NF-ΚB signaling pathway in PASMCs. Western blot analysis was performed to detect the levels of p-IRAK, IRAK, p-IKK, IKK, p-IκB, IκB and NF-κB p65, and the representative blot results are shown. TLR4, Toll-like receptor 4; IRAK, interleukin-1 receptor-associated kinase; NF-κB, nuclear factor-κB; PASMCs, pulmonary artery smooth muscle cells; IKK, IκB kinase; LPS, lipopolysaccharide.
