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. 2017 Jul 5;16(3):2604–2610. doi: 10.3892/mmr.2017.6925

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Overexpression of miR-433 inhibits apoptosis in Min-6 pancreatic β cells induced by high-glucose. (A) Apoptosis of Min-6 cells transfected with miR-433 mimics or siCOX2 cells and cultured in 5 mmol/l or 11 mmol/l glucose following Annexin-V-FITC/PI staining and flow cytometric analysis. (B) Statistical analysis of apoptotic cells in (A) from Min-6 cells exposed to different treatments. Data are expressed as the mean ± standard deviation; ***P<0.001. COX2, cyclooxygenase 2; FITC, fluorescein isothiocyanate; miR, microRNA; PI, propidium iodide; siCOX2, COX2-directed siRNA; NC, negative control siRNA; siRNA, short interfering RNA.