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. 2017 Jul 17;40(3):721–730. doi: 10.3892/ijmm.2017.3068

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Copyright: © Wu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Effects of Tripterygium wilfordii Hook. f. (GTW) on the glomerular morphological changes in the 4 groups. (A) Light microscopy, periodic acid-Schiff (PAS) (magnification, ×400). (B) Light microscopy, Masson staining (magnification, ×400). (C) The number of glomerular cells. (D) The rate of extracellular matrix (ECM)/glomerular area. (E) The rate of collagen/glomerular area. (F) Electron microscopy, ×1,700. The arrows in (F-c) indicate foot process effacement and glomerular basement membrane (GBM) thicking respectively. The arrows in (F-d) indicate the recovered foot process and GBM respectively. (a) Sham group, (b) sham + GTW group, (c) vehicle group and (d) GTW group. Data are expressed as mean ± SE. ^**P<0.01 vs. the sham group; ^##P<0.01 vs. the vehicle group at week 8 after drug-intervention.