Table 2.
MIC distribution patterns, ECOFFs and range of the different clusters in the whole data collection.
| Class (subclass) | Antimicrobial | MIC distribution pattern | ECOFF (μg/mL) | Wild type cluster (μg/mL) | Non wild type clusters (μg/mL) |
|---|---|---|---|---|---|
| Beta lactams | |||||
| (Penams) | Amoxicillin | Unknown | 0.12* | ≤0.03–0.12 | 0.5–4 |
| AMC | Unknown | 0.25* | ≤0.03–0.25 | 0.5–4 | |
| Penicillin | Unknown | 0.03* | ≤0.03 | 0.06–4 | |
| (Cephalosporins) | Ceftiofur | Unimodal | NA | 0.03–8 | NA |
| Cefquinome | Unimodal | NA | 0.002–0.5 | NA | |
| Amphenicols | Florfenicol | Unimodal | NA | 0.5–4 | NA |
| Pleuromutilins | Tiamulin | Multi-modal | 2 | 0.06 – >2 | 4 – >64 |
| Tetracyclines | Tetracycline | Multi-modal | 4 | 0.25–4 | 16 – >128 |
| Doxycycline | Multi-modal | 0.5 | 0.06–0.5 | 4–64 | |
| Erythromycin | Multi-modal | 0.12 | 0.015–0.12 | 2 – >32 | |
| Macrolides | Tylosin | Multi-modal | 4 | 0.25–4 | 128 – >256 |
| Tilmicosin | Multi-modal | 32 | 0.5–32 | >128 | |
| Lincosamides | Lincomycin | Multi-modal | 0.25* | 0.06–0.25 | 0.5 – >128 |
| Aminocyclitol | Spectinomycin | Multi-modal | 64 | 4–64 | ≥512 |
| Fluoroquinolones | Enrofloxacin | Multi-modal | NA | NA | 0.12–4 and >8 |
| Marbofloxacin | Multi-modal | 0.015 | 0.015 | 0.25–2 and 16 | |
| Potentiated sulphonamides | TMPS | Multi-modal | 0.12* | 0.015–0.12 | 0.25 – >32 |
Note: Antibiotics including florfenicol, ceftiofur and cefquinome presented a unimodal distribution therefore ECOFF values were not set and NWT cluster were not considered. Wild-type cluster was not considered in the case of enrofloxacin.
AMC: Amoxicillin/Clavulanate. TMPS: Trimethoprim/Sulfamethoxazole. NA: Not applicable (ECOFF were unable to be defined in this sample set).
*Tentative cut-off for the most susceptible cluster.