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. 2017 Aug;207:117–124. doi: 10.1016/j.vetmic.2017.06.002

Table 2.

MIC distribution patterns, ECOFFs and range of the different clusters in the whole data collection.

Class (subclass) Antimicrobial MIC distribution pattern ECOFF (μg/mL) Wild type cluster (μg/mL) Non wild type clusters (μg/mL)
Beta lactams
(Penams) Amoxicillin Unknown 0.12* ≤0.03–0.12 0.5–4
AMC Unknown 0.25* ≤0.03–0.25 0.5–4
Penicillin Unknown 0.03* ≤0.03 0.06–4
(Cephalosporins) Ceftiofur Unimodal NA 0.03–8 NA
Cefquinome Unimodal NA 0.002–0.5 NA
Amphenicols Florfenicol Unimodal NA 0.5–4 NA
Pleuromutilins Tiamulin Multi-modal 2 0.06 – >2 4 – >64
Tetracyclines Tetracycline Multi-modal 4 0.25–4 16 – >128
Doxycycline Multi-modal 0.5 0.06–0.5 4–64
Erythromycin Multi-modal 0.12 0.015–0.12 2 – >32
Macrolides Tylosin Multi-modal 4 0.25–4 128 – >256
Tilmicosin Multi-modal 32 0.5–32 >128
Lincosamides Lincomycin Multi-modal 0.25* 0.06–0.25 0.5 – >128
Aminocyclitol Spectinomycin Multi-modal 64 4–64 ≥512
Fluoroquinolones Enrofloxacin Multi-modal NA NA 0.12–4 and >8
Marbofloxacin Multi-modal 0.015 0.015 0.25–2 and 16
Potentiated sulphonamides TMPS Multi-modal 0.12* 0.015–0.12 0.25 – >32

Note: Antibiotics including florfenicol, ceftiofur and cefquinome presented a unimodal distribution therefore ECOFF values were not set and NWT cluster were not considered. Wild-type cluster was not considered in the case of enrofloxacin.

AMC: Amoxicillin/Clavulanate. TMPS: Trimethoprim/Sulfamethoxazole. NA: Not applicable (ECOFF were unable to be defined in this sample set).

*Tentative cut-off for the most susceptible cluster.