Table 1.
Transporters with higher (A) and lower (B) expression in human Wilson’ disease liver compared to control livers
| Gene ID | Protein name | Transported solute |
|---|---|---|
| (A) | ||
| AL518391 | Aquaporin 1 (Colton blood group) | H2O |
| AK025062 | SLC12, member 2 | Na, K/Cl |
| NM_000492 | CFTR | Cl |
| AI638295 | Chloride intracellular channel 6, CLC6 | Cl |
| BF247552 | SLC38A1 | Glutamine |
| U51478 | Na+/K+ ATPase, beta 3 | Na/K |
| NM_018658 | KCNJ16 channel | K |
| NM_000165 | Gap junction protein, alpha 1, 43 kDa | Solutes |
| NM_006931 | SLC2A 3 | Glucose, sugars |
| AF034607 | Chloride intracellular channel 1, CLC1 | Chloride |
| NM_000701 | Na+/K+ ATPase, alpha 1 | Na/K |
| NM_004731 | SLC16A7 transporter 2 | Pyruvate, lactate |
| AW068936 | ATP11A | Phospholipid? |
| BG150485 | SLC 6A6 (2-aminoethanesulfonic acid) | Taurine and b-alanine |
| BC000006 | Na+/K+ ATPase, beta 1 polypeptide | Na+/K+ |
| NM_004207 | SLC16A 3 | Monocarboxylic acid |
| NM_01421 | GABRP (GABA receptor) | Cl |
| NM_002560 | Purinergic receptor P2RX4 | Ca2+ |
| AI539710 | ABCC1 | As-triglutathion |
| (B) | ||
| BF514158 | Potassium channel, subfamily J, member 8 | K+ |
| N80922 | SLC 35 (dual transporter), member D1 | UDP-glucuronic acid and UDP-N-acetylgalactosamine |
| NM_000443 | SLC22A 7 | Organic acid |
| N30257 | SLC16A 10 | Aromatic amino acid |
| NM_003051 | SLC16A 1 | Monocarboxylic acid |
| AW268880 | SLC25A13 | Aspartate, glutamate |
| AL136828 | SLC41A 2 | Magnesium |
| BF433180 | Na+/H+ exchanger domain containing 2 | Na+/H+ |
| NM_030777 | SLC 2, member 10 | Glucose |
| NM_173596 | SLC 39, member 5 | divalent metal ions |
| NM_018043 | Anoctamin 1, Ca-activated chloride channel | Cl |
| NM_000166 | Gap junction protein, beta 1, 32 kDa | Solutes, metabolites |
| NM_006672 | SLC 22A 7 | Organic anion |
| NM_001859 | SLC 31A1 | Cu |
| AA834576 | Inositol 1,4,5-triphosphate receptor, type 2 | Ca2+ |
| AB040120 | SLC 39, member 8 | Zn2+ |
| BC001689 | SLC 25A20 | Carnitine/acylcarnitine |
| NM_020980 | AQP9 | Glycerol |
| NM_006841 | SLC 38A 3 | Glutamate |
| AA876372 | SLC 7A2 | Cationic amino acid |
| AL157452 | SLC 1, member 2 | Glutamate |
| NM_014252 | SLC25, member 15 | Ornitine |
| R52647 | Ca++ATPase, plasma membrane 2 | Ca2+ |
| AW235061 | SLC 1 member 1 | Glutamate |
| AY008285 | SLC25A18 | Glutamate |
| AF153330 | SLC 19, member 2 | Thiamine |
| AI074459 | ABCC6 | Lipid, bile acid |
| AF098951 | ATP-binding cassette, sub-family G (WHITE), member 2 | Retinal |
| NM_006517 | SLC16A2 | Thyroid hormone |
| SLC21A6 | Taurochlate, steroid conjugates prostaglandin E2 | |
| BF475862 | ATPase, class VI, type 11C | Lipids (?) |
| BC020618 | ABCB4/MRP3 | Lipid, drugs |
| AI272941 | TRPM8 channel | Cations |
| NM_007168 | ABCA8 | Drugs |
| NM_019844 | SLC1B3 | Organic anion |
| AA777852 | SLC 22, member 7 | Organic anion |
| AI797218 | SLC 13, member 5 | Na citrate |
| AI003579 | SLC 6, member 1 | GABA |
| NM_003049 | SLC 10, member 1 | Bile acid |
| NM_021614 | K+ channel, subfamily N, member 2 | K+ |
| NM_000340 | SLC 2, member 2 | Glucose |
| AF193836 | SLC38, member 4 | Amino acid |
| M_005835 | SLC17, member 2 | Phosphate |
| NM_018242 | SLC 47A1 | Flavonoid |
| NM_003057 | SLC22A1 | Choline, histamine, epinephrine, adrenaline, noradrenaline, dopamine |