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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Dev Dyn. 2017 Jun 28;246(8):625–634. doi: 10.1002/dvdy.24524

Figure 4. Developmental loss of axonemes causes BAV.

Figure 4

(A) Control IHC experiments for the ciliary axoneme (green), basal body (red), and nuclei (blue) show normal cilia length on control aortic valves (top) vs. axoneme shortening in the Ift88 conditional knockout (bottom). (B) H and E and 3D reconstruction of P0 wild type and conditional knockout valves. Wild-type valves show three distinct cusps while conditional knockout mouse aortic valves show bicuspid aortic valves. Penetrance of the phenotype is depicted below the 3D reconstruction images. RC=right coronary, LC= left coronary, NC= non-coronary, and RNC= right non-coronary.