Figure 2.

Dose-response relationship of intraperitoneal (IP) injection doses of domoic acid (DA) and the percent of animals affected at each dose for male and female C57BL/6NJ mice (n = 4 at each dose for each sex). Hind limb scratching was used to quantify excitotoxicity in mice and EC50s were the same for male and female mice. Effective concentration (EC50) = the dose at which 50% of the mice tested exhibited hind limb scratching.