Figure 3.

Spatial learning and memory outcomes tested using a radial water tread maze (RWTM) in mice that were exposed to low-level asymptomatic doses of domoic acid via intraperitoneal (IP) injection once a week for A) one, B) six, and C) 25 weeks, and at a recovery time point nine weeks after cessation of toxin exposure (D). Percent successful escape levels were not significantly different at the one and six week exposure time points, but were significantly lower in exposed mice at the 25-week exposure time point compared to controls. After a nine-week recovery period with no toxin exposure, percent successful escape levels on memory test days five and 12 were no longer significantly different between exposed and control mice (D). Statistically significant p values are shown; ns = not significant