Figure 6.

Spatial learning and memory outcomes tested using a radial water tread maze (RWTM) at three old age time points A) 18, B) 24 and C) 28 months of age in control mice and mice that were exposed to low-level asymptomatic doses of domoic acid via intraperitoneal (IP) injection once a week for 36 weeks from three months of age to one year of age (Figure 1B). Spatial cues were the same between 18 and 24 month time points, but were changed between the 24 and 28 month time points to create a novel learning challenge. Impairment was not observed as measured by percent successful escape levels suggesting that long term early life exposure did not significantly impact cognitive function with age and that recovery from the impairments observed immediately following 25 weeks of exposure as shown in Figure 3D was maintained into old age. ns = not significant