Table 1. Comparison of Prenatal Screening Options^1,28–31.

	cfDNA Screening	First Trimester Screening	Second Trimester Screening (Quad Screen)	Integrated Screen (NT, PAPP-A, Quad Screen)
Gestational age	>10 wk	11–14 wk	15–24 wk	PAPP-A: 9–13 wk NT: 10–13 wk Quad screen: 15–24 wk
Detection rate
Trisomy 21	99.2	82–87	81	94–96*
Trisomy 18	96.3	81	60	90†
Trisomy 13	91.0	Limited data	N/A	Limited data

^*Detection rate for trisomy 21 of a fully integrated screen that includes a nuchal translucency measurement.

^†Detection rate of trisomy 18 of a serum integrated screen.

NT indicates nuchal translucency; N/A, not applicable.