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IL-22RA2 neutralizes the IL-22 activity in a BaF3 proliferation assay. (A) IL-22-CEE shows dose-dependent proliferative activity on BaF3 cells coexpressing IL-22RA1 and CRF2–4 (●), but not CRF2–4 alone (▵). The IL-22-CEE activity is completely blocked with the addition of 10 nM IL-22RA2-Fc4 fusion protein (○). (B) Dose-dependent inhibition of 60 pM IL-22-CEE activity by IL-22RA2-Fc4. Error bars indicate the standard deviation of triplicate samples.
