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. 2017 Jul 17;13:1744806917719169. doi: 10.1177/1744806917719169

Figure 5.

Figure 5.

The effect of calpain inhibitor MDL 28170 on mechanical allodynia and sprouting of myelinated afferent fibers into the spinal lamina II. (a) Time course of the MDL 28170 effect on RTX-induced mechanical allodynia. The black arrow indicated MDL 28170 injection time; B: baseline. Data are expressed as means ± SEM (n = 9 rats in each group). (b) Representative images show CTB immunoreactive myelinated fibers in the spinal dorsal horn of vehicle, RTX 6W, MDL 28170, and PEG400/DMSO groups. Scale bar, 50 µm. Dotted line marks the division separating lamina II and III. White arrows stands for sprouting of myelinated fibers in lamina II. (c) Summary data show the area of CTB-labeled afferent terminals in lamina II in different groups. Data are expressed as means ± SEM (n = 3 rats in each group). *P < 0.05, compared with the vehicle group. #P < 0.05, compared with the PEG400/DMSO group.