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. Author manuscript; available in PMC: 2017 Aug 8.
Published in final edited form as: Gene Ther. 2014 Nov 27;22(2):209–215. doi: 10.1038/gt.2014.104

Figure 4.

Figure 4

(a) Bioluminescent imaging of systemic Raji tumor progression in Rag2−/−γc−/− mice following T-cell infusion. Mice inoculated intravenously with Raji/Luc cells on day 0 were infused with CD19-CAR T-cells alone on day 3 (T-cell treatment group, n =3) or in combination with three intraperitoneal injections of an anti-PD-1 antibody (n =4), whereas mice in the control group did not receive T-cells (n =4). (b) Quantitative bioluminescence imaging on day 27 as shown in panel (a). (c) Raji tumor-bearing mice were infused with CD19-CAR T-cells alone (n =3) on day 3 or in combination with a single intramuscular injection of AAV-IL-7 (n =4). (d) Quantitative bioluminescence image on day 27 as shown in panel (c). Bioluminescent imaging was performed on days 13, 20 and 27. *P<0.05, **P<0.01.