Table 2.
Hazard Ratios for Melanoma-Related Death, According to Multivariable Prognostic Factors.*
| Prognostic Factor | Dissection | Observation | ||
|---|---|---|---|---|
| Hazard Ratio (95% CI) | P Value | Hazard Ratio (95% CI) | P Value | |
| Sex: male vs. female | 1.13 (0.80–1.59) | 0.50 | 1.41 (0.98–2.05) | 0.07 |
|
| ||||
| Age, per 1-yr increase | 1.00 (0.99–1.01) | 0.93 | 1.01 (0.99–1.02) | 0.15 |
|
| ||||
| Breslow thickness | ||||
|
| ||||
| <1.50 mm† | 1.00 | 1.00 | ||
|
| ||||
| 1.50–3.50 mm | 1.64 (0.96–2.79) | 0.07 | 2.46 (1.34–4.53) | 0.004 |
|
| ||||
| >3.50 mm | 3.82 (2.19–6.66) | <0.001 | 4.32 (2.31–8.09) | <0.001 |
|
| ||||
| Ulceration: present vs. absent | 1.97 (1.40–2.77) | <0.001 | 2.17 (1.55–3.05) | <0.001 |
|
| ||||
| Site of melanoma | ||||
|
| ||||
| Arm or leg† | 1.00 | 1.00 | ||
|
| ||||
| Head or neck | 0.81 (0.44–1.48) | 0.49 | 1.60 (0.96–2.66) | 0.07 |
|
| ||||
| Trunk | 1.26 (0.89–1.77) | 0.19 | 1.05 (0.74–1.49) | 0.80 |
|
| ||||
| No. of positive sentinel nodes | ||||
|
| ||||
| 1† | 1.00 | 1.00 | ||
|
| ||||
| 2 | 1.08 (0.71–1.62) | 0.73 | 1.27 (0.87–1.84) | 0.21 |
|
| ||||
| ≥3 | 1.17 (0.61–2.24) | 0.64 | 2.01 (0.82–4.95) | 0.13 |
|
| ||||
| Nonsentinel nodes: positive vs. negative | 1.78 (1.19–2.67) | 0.005 | NA | |
*
Patients with positive findings on RT-PCR were excluded from this analysis. NA denotes not applicable.
†
This group served as the reference group.