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. Author manuscript; available in PMC: 2017 Aug 8.
Published in final edited form as: Mol Pharm. 2017 May 19;14(6):1852–1860. doi: 10.1021/acs.molpharmaceut.6b01015

Figure 3.

Figure 3

Serum stability of colloidal formulations by FPLC. Traces show separation between serum proteins (absorbance at 280 nm) and (A) fulvestrant–UP80 colloids (tracked by fluorescence using a BODIPY FRET pair) and (B) PPD–PLAC–PEG colloids (unique absorbance at 480 nm) at t = 0. (C) Comparison of the peak area under the colloid curve over time to the area at t = 0 h to determine colloid stability as a function of time. Both colloids are stable up to 24 h, with fulvestrant–UP80 colloids dissociating between 24 and 48 h and PPD–PLAC–PEG colloids showing no evidence of dissociation over 48 h.