(a) Research workflow. MDACC, The University of Texas M.D. Anderson Cancer Center; GWAS, genome-wide association study; SNP, single-nucleotide polymorphism; HWE, Hardy Weinberg equilibrium; MAF, minor allele frequency. (b) Manhattan plot of associations between 19,830 SNPs and CMSS. There are 1,855 SNPs with P < 0.05. The blue horizontal line indicates P = 0.05.