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. Author manuscript; available in PMC: 2018 Jul 5.
Published in final edited form as: Neuron. 2017 Jun 22;95(1):169–179.e3. doi: 10.1016/j.neuron.2017.06.007

Figure 5. Removal of PNNs in the auditory cortex using ChABC before auditory fear conditioning decreased fear expression observed 24 and 48 hours later, but did not decrease fear expression 30 minutes later.

Figure 5

ChABC or saline was injected into the auditory cortex of mice 72 hours prior to Pavlovian auditory fear conditioning. Mice were fear-conditioned and no differences were observed in fear acquisition (A) or fear expression 30 minutes after fear conditioning (B) between saline and ChABC groups (C). Decreased fear expression was observed in ChABC injected mice in comparison to controls at 24 hours after fear conditioning (D) wherein significant differences between groups were observed during CS1–5 and CS6–10 (E) and at 48 hours after fear conditioning during CS1–5 and CS11–15(F). *P < 0.05 vs. vehicle. All values are means ±SEM