Table 1.

SNP frequencies in French Caucasian case-control study

							X2P values
Variants		Subject	NN	NM	MM	Multiple allele frequency	HWE*	Additive†	Codominant‡	Recessive§	Dominant¶
KLF11
1	Adjacent sequence (AS)	Control	244	62	4	0.11	0.98
	−1,659 G>C	T2DM	202	88	8	0.17	0.67	0.0022	0.0084	0.22	0.0023
7	Promoter −86 del/ins		5-5	5-4/5-6	4-4/4-6/6-6	4/6
	(GCC)∥	Control	145	127/16	20/2/0	0.27/0.03	0.24			0.08‡‡	0.15‡‡
		T2DM	130	129/6	31/1/0	0.32/0.01	0.76	0.03**	0.17††	0.31§§	0.07§§
9	Exon 2 + 185 A>G,	Control	252	58	3	0.10	0.87
	Gln62Arg	T2DM	211	95	7	0.17	0.33	0.00023	0.00083	0.20	0.00019
11	Exon 3 + 1185 A>T,	Control	202	96	13	0.20	0.71
	Val395Val	T2DM	192	100	7	0.19	0.15	0.81	0.39	0.20	0.85
12	IVS3 + 976 T>C	Control	198	96	14	0.20	0.59
		T2DM	191	102	8	0.20	0.19	0.82	0.39	0.21	0.83
14	IVS3 + 1,331 T>C	Control	282	30	1	0.05	0.83
		T2DM	262	22	0	0.04	0.50	0.30	0.46	0.34	0.35
16	IVS3 + 1,398 del(A)	Control	239	57	2	0.10	0.48
		T2DM	192	93	7	0.17	0.27	0.00055	0.0021	0.09	0.000077
17	AS + 343 G>T	Control	240	64	2	0.11	0.56
		T2DM	207	89	7	0.17	0.68	0.0031	0.0096	0.09	0.0047
18	AS + 1,357 C>T	Control	194	91	13	0.20	0.58
		T2DM	195	101	9	0.20	0.34	0.96	0.56	0.36	0.76
Non-KLF11
2	TAF1B-SL1 + 16 T>G,	Control	88	138	64	0.46	0.48
	Ser6Ala	T2DM	97	139	61	0.44	0.41	0.51	0.81	0.65	0.55
6	LBP32 + 1189 C>T,	Control	180	111	14	0.23	0.63
	Ile419Val	T2DM	183	108	12	0.22	0.50	0.67	0.90	0.70	0.73
17	KLF11 AS + 2,541 A>G	Control	240	61	3	0.11	1.00
		T2DM	214	88	6	0.16	0.53	0.0069	0.022	0.32	0.0064
21	AK091299 UTR	Control	245	59	4	0.11	0.77
	+2,422 A>T	T2DM	207	87	7	0.17	0.68	0.0028	0.095	0.34	0.0024
25	AK091299 UTR	Control	174	123	10	0.23	0.04§§
	+3,107 G>A	T2DM	154	128	22	0.28	0.57	0.05	0.06	0.03	0.14
44	rs7587317 (genomic)	Control	263	145	19	0.21	1.00
		T2DM	180	108	16	0.17	1.00	0.08	0.22	0.10	0.33
47	RRM2 IVS8-177 A/G	Control	163	142	26	0.29	0.60
		T2DM	171	118	17	0.25	0.65	0.07	0.19	0.10	0.07

Frequency analysis of variants showing a suggestive T2DM association in a pilot study (P < 0.2).

^*X² test for deviations from the Hardy-Weinberg equilibrium.

^†X² test for differences of allele frequencies between control and T2DM subjects.

^‡X² test for differences of genotype frequencies between control and T2DM subjects under a codominant model.

^§X² test for differences of genotype frequencies between control and T2DM subjects under a recessive model.

^¶X² test for differences of genotype frequencies between control and T2DM subjects under a dominant model.

^∥Triallelic variant with four, five, and six GCC repeats that was analyzed in a 2 × 3 contingency table with genotype frequencies.

^**Triallelic variant with four, five, and six GCC repeats that was analyzed with allele frequencies and a 2 × 6 contingency table with genotype frequencies.

^††Analyses in the recessive model of 4-4 alleles vs. all others, and in the dominant model of 4-4, 4-5, and 4-6 alleles vs. 5-5 and 5-6 alleles.

^‡‡Analyses in the recessive model of 6-6 alleles vs. all others, and in the dominant model of 5-6, 4-6, and 6-6 alleles vs. 5-5, 5-4, and 4-4 alleles.

^§§Deviated from HWE, 3.2% of the genotypes were reanalyzed without observing errors. By using an Armitage's trend test, which is robust to Hardy-Weinberg (13), this SNP is associated with T2DM, P = 0.04.