Table 2. Frequency of Gln62Arg KLF11 in additional population samples.

						OR (95% Cl), X2P value
Sample	NN	NM	MM	n	Minor allele frequency	Allele frequency	Dominant model
Initial familial study
Normoglycemic	252	58	3	313	0.102	1.85(1.33-2.57)	2.00(1.39-2.87)
T2DM subjects	211	95	7	313	0.174	0.00023	0.00019
Second set
Normoglycemic	1,138	307	18	1,463	0.117	1.18(1.01-1.38)	1.18(1.00-1.40)
T2DM subjects	1,032	326	25	1,383	0.136	0.034	0.057
Overall
Normoglycemic	1,390	365	21	1,776	0.115	1.29(1.12-1.49)	1.32(1.13-1.54)
T2DM subjects	1,243	421	32	1,696	0.143	0.00033*	0.00054*

NN, homozygous wild-type allele carriers; NM, heterozygous allele carriers; MM, homozygous mutant allele carriers; OR, odds ratio.

^*P value and combined OR for allelic effects calculated by a Mantel-Haenszel test (25).