Table 3.

fMRI Stroop Changes At Post-Treatment vs. Beginning-of-Treatment and Associations With Treatment Components

			Peak Coordinates				Statistics (t-value)
Cluster Label (Peak)	Regions of Activation	R/L	x	y	z	k	Maximum Voxel	Cluster Mean
A. Change in fMRI Stroop Effect at Post-Treatment vs. Beginning-of-Treatment (Trial Type (Inc, Con) × Session (Post, Beginning)) (N=26)
Culmen	L Culmen, L Parahippocampal Gyrus	L	−9	−36	−9	188	−5.45	−3.29
	L Precuneus, L Lingual Gyrus, L Posterior	L	−9	−60	24
Precuneus	Cingulate					269	−5.05	−3.29
Cingulate Gyrus	R/L Cingulate Gyrus	R	9	9	42	144	−4.63	−3.30
Postcentral Gyrus	R Postcentral Gyrus, R Precentral Gyrus	R	39	−18	33	83	−4.57	−3.14
	L Angular Gyrus, L Middle Temporal Gyrus, L
Angular Gyrus	Superior Temporal Gyrus	L	−33	−75	36	77	−4.52	−3.27
Thalamus	L and R Thalamus, R Caudate	L	−3	0	0	139	−4.51	−3.20
Hippocampus	R Hippocampus, R Amygdala, R Parahippocampal	R	30	−21	−15	109	−4.28	−3.23
Precentral Gyrus	R Precentral Gyrus	R	60	6	3	96	−3.99	−3.14
B. Whole Brain Correlations between ‘Change in fMRI Stroop Effect’ and Treatment Engagement and Outcome
i. Correlation between ‘Change in fMRI Stroop Effect’ and Number of CBT Sessions (N=26)
Precentral Gyrus	L Precentral Gyrus	L	118	−36	−15	48	−0.75	−0.55
Inferior Parietal Lobule	R Inferior Parietal Lobule	R	74	33	−36	39	−0.73	−0.56
Middle Frontal Gyrus	L Middle Frontal Gyrus	L	61	−42	33	27	−0.72	−0.57
Medial Frontal Gyrus	R Medial Frontal Gyrus, L/R Precentral Gyrus, L/R	R	194	6	−15	69	−0.70	−0.55
ii. Correlation ‘Change in fMRI Stroop Effect’ and Total Number of Contingency Management Prizes (within CM Group, N=14)
Postcentral	R Postcentral	R	51	45	−18	39	−0.93	−0.73
Postcentral	L Postcentral, L Precentral Gyrus	L	58	−33	−24	45	−0.91	−0.73
iii. Correlation between ‘Change in fMRI Stroop Effect’ and Number of Days of Disulfiram Treatment Taken (N=10)
No Significant Clusters
iv. Correlation between ‘Change in fMRI Stroop Effect’ and Percent Days Cocaine Abstinent During Treatment Period (N=26)
Superior Temporal Gyrus	R Superior Temporal Gyrus, R Transverse Temporal	R	63	−12	12	72	0.72	0.55

Note. All results presented survive family wise error correction for multiple comparisons at the whole brain level to two-tailed p_FWE<.05.

Section A shows clusters that survived corrections for mutliple comparisons that showed a change in ‘Stroop effect’ related activity in the sample overall at post-treatment versus beginning-of-treatment (N=26).

Section B shows clusters that survived corrections for multiple comparisons from separate whole-brain rank-order non-parametric correlations with the change in Stroop effect contrast and measures of treatment engagement (i. Number of Cognitive Behavioral Therapy (CBT) Sessions (N=26); ii. Total Number of Contingency Management (CM) Prizes within those randomized to CM (N=14); iii. Number of Days of Disulfiram Treatment Taken within those randomized to medication (N=10)); and within-treatment cocaine use (iv. Percent Days Cocaine Abstinent During the Treatment Period (N=26)).

Abbreviations: Inc= incongruent trials, Con=congruent trials, Beginning= beginning-of-treatment, Post=post-treatment, R=right, L=left, k=cluster size (in voxels), CM=contingency management; CBT= cognitive behavioral therapy.

The figures which correspond to the these results are as follows: For section A, see Figure 1A, extracted cluster means in Figure 1B, and “whole-brain” slice-out images in Supplemental Figure 2 (as well as full slice-out images for the beginning of treatment Stroop effect and post-treatment Stroop effect contrasts separately in Supplemental Figure 1). For section B, see Figure 2 and “whole-brain” slice-out images in Supplemental Figure 3.