Table 1.

MMP inhibitors, their specificity to MMPs (K_i or IC₅₀ <1 nM to 10 µM), and their effects in preclinical trials.

MMP Inhibitor Category, Number, Chemistry, Other Name		MMP Specificity, IC50 or Ki					Preclinical Trial
		<1 nM	1–10 nM	11–100 nM	0.1–1 µM	1–10 µM
1	ZBGs, Hydroxamic Acids						Glioblastoma, breast, lung, ovarian, and prostate cancer
	Succinyl Hydroxamate
	Batimastat (BB-94)		1, 2, 8, 9	3
	Marimastat (BB-2516)		1, 2, 9, 14	7
	Ilomastat (GM6001, Galardin)	1, 2, 8, 9, 26	7, 12	3, 14
2	Sulfonamide Hydroxamate, AG3340, Prinomastat	2, 3, 9, 13, 14	1	7			Neovascularization, lung and prostate cancer, uveal melanoma, gliomas
3	Succinyl Hydroxamate		1
4	RS-104966	13		1
7	Sulfonamide Hydroxamate	2	8, 9, 14		1, 3	7	Decrease tumor invasion
8	Sulfonamide Hydroxamate		3		2	9	Chronic non-healing wounds
10				2, 3		1
12						3
5	Carboxylic Acids		13	3, 8	2	7, 9, 14	Osteoarthritis
6			11		3, 12	1, 9, 14	Chronic obstructive pulmonary disease
9	Sulfonylhydrazides		2, 9	1	7	3
16	Thiol- and Cyclic Mercaptosulfides	9	2	1, 7, 14	3
19	Aminomethyl Benzimidazoles				11	2, 9, 13
	Phosphorous-Based
17	Sulfonamide Phosphonate	8	2	3
18	Sulfonamide Phosphonate		8	2, 9, 13, 14	1, 3	7	Liver disease, multiple sclerosis, breast cancer
20	Carbamoyl Phosphonate			2			Melanoma
21	Carbamoyl Phosphonate					2	Melanoma, prostate cancer
	Nitrogen-Based
22	Oxazoline					11
23	Dionethiones and Pyrimidine-2,4,6 triones, Ro-28-2653		2, 14	8, 9		3	Anti-angiogenic and anti-invasive in tumor models
24	Dionethiones and Pyrimidine-2,4,6 triones	13			2, 9, 12		Osteoarthritis
	Heterocyclic Bidentate Chelators
25	Terphenyl Backbone, AM-6			3
26	Biphenyl Backbone, 1,2 -HOPO-2			8, 12	2, 3	13	Cardiac ischemia /reperfusion injury
27	Diphenyl Ether Backbone		2, 9, 13	3		1	Brain edema following ischemia/reperfusion
28	Biphenyl Backbone, Pyrone-based			3, 9, 12	8	2, 13
29	Biphenyl Backbone, Hydroxypyridinone Derivative					8, 12
30	Biphenyl Backbone, AM-2			8, 12	−3	−2
31	Biphenyl Backbone					2, 8, 12, 13
34	Non-ZBGs			13			Osteoarthritis
35				12	2, 8, 13	3, 9
36						2, 8, 13
37		13					Osteoarthritis
38	Pyrimidine Dicarboxamide					13
39	Pyrimidine Dicarboxamide			13
	Mechanism-Based
40	Diphenyl Ether Backbone, SB-3CT			2	9, 14	3	Inhibits liver metastasis in T-cell lymphoma and bone metastasis in prostate cancer
42	Diphenyl Ether Backbone, Thiol-Containing			2, 9	14	3
43	Diphenyl Ether Backbone		2	14	9	3
45	Diphenyl Ether Backbone		9	2	3, 14

For details and original references see.^{11,78,319,320}