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Change in Lipoprotein (a) levels by HCAR2 (rs2454727) genotype in white subject from the AIM-HIGH trial. The reduction in Lp(a) in response to niacin was greater in homozygous 317M carriers compared with 317I carriers (p=0.0053 in the niacin group; p=0.37 in the placebo group; p-interaction =0.005). The boxes on the boxplots represent the 75th percentile, median, and 25th percentile.
